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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name VEGF siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line mouse embryonic fibroblast cell line NIH3T3
Methods siRNA transfection, semi-qPCR, ELISA
Expression pattern associated
Functional description siRNA-VEGF can be expressed across the retina and that long-term suppression of CNV is possible through the use of stable AAV2/8-mediated siRNA-VEGF expression.
PubMed ID 24744609
Year 2014
Title Adeno-associated virus type 8 vector-mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model.
Drug-related ncRNA NO

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